Is it necessary to rotate the front and rear tires at 45,000 kilometers?

I've been using the 2017 MDX for over a year, and the front tires are wearing out unevenly. After rotating the rear tires to the front and doing an alignment, the newly replaced tires are again showing severe uneven wear. Have any other car owners experienced this situation? Looking for advice.

The Vellfire has been driven over 40,000 kilometers, and there's a lot of noise coming from the rear tires. Upon inspection, the inner tires are worn, and both tires are the same. What could be causing this?

If we're talking about the SP model, is it necessary to choose 21-inch wheels? Would the 30 aspect ratio rear tires be prone to bulging easily?

Is it difficult to distinguish the front and the rear?

Is it necessary to change the transmission oil at 40,000 kilometers?

Is it necessary to change the tires? They've been used for 3 years and 60,000 kilometers, and I'm planning to go on a long road trip.

Is it necessary to change the tires? 3 years and 60,000 kilometers, planning to go on a long trip.

Is it necessary to rotate the front and rear tires at 45,000 kilometers?

Are there any fellow drivers experiencing severe rear tire wear? After 30,000 kilometers, the rear tire treads are down to the warning line...

Is there a problem if the tire pressures are different? Front left 240, rear left 250, front right 240, and rear right 233. Is it okay to drive?